Clinical-laboratory characteristics of psoriasis patients with metabolic syndrome

I.Ya. Horbachevsky Ternopil State Medical University

Ternopil

Bolotiuk M V
Halnykina S O

Introduction & Objectives: 60 psoriasis patients with the metabolic syndrome (MS) have been observed. Having examined psoriasis patients with the metabolic syndrome (MS), 22 (36,67%) patients were diagnosed with plaque psoriasis, 32 patients (53,33%) – with psoriatic arthritis and 6 patients (13,33%) – with erythrodermic psoriasis. The number of the examined female patients and the examined male patients made up 8 (13,33%) and 52 (86,67%) respectively. The age of the patients was different, however, the average age of the most patients – 42 people (70%) was 31-50 years. During the analysis of the received data, the psoriasis patients were didvided into three groups according to the degree of psoriatic severity with the indices of PASI score: 0 patients were assessed with the mild psoriatic degree; 50 patients (83,33%) – with the moderate psoriatic severity degree and 10 patients (16,67%) – with the severe psoriatic degree. Materials & Methods: Taking into account the diagnostic criteria of the metabolic syndrome of the International Diabetes Federation (IDF, 2005). Results: The significant increase (p<0,05) of the following indices was observed in our study: general obesity (Quetelet index) (М ± 2m1 = 30,06 ± 2,84; М ± 2m2= 32,13 ± 1,06), waist circumference (М ± 2m1 = 90,86 ± 7,3; М ± 2m2= 98,19 ± 1,48), triglycerides (М ± 2m1 = 1,64 ± 0,08; М ± 2m2= 2,07 ± 0,08), glucose tolerant test (М ± 2m1 = 7,66 ± 0,18; М ± 2m2= 9,26 ± 0,86), fibrinogen level in the blood serum (М ± 2m1 = 3,77 ± 0,5; М ± 2m2= 4,21 ± 0,06), peripheral blood glucose level (М ± 2m1 = 5,3 ± 0,38; М ± 2m2= 5,78 ± 0,44), the increased indices of the arterial blood pressure level (М for females –– systolic arterial pressure =138,7; diastolic arterial pressure =89,3. М for males – systolic arterial pressure =138,4; diastolic arterial pressure =88,2. М general – systolic arterial pressure =138,5; diastolic arterial pressure =88,4). The significant decrease (p<0,01) of the high-density lipoprotein cholesterol (М ± m = 1,18 ± 0,12) has been revealed. It is interesting that B fibrinogen level (n=60) is positive in 58 patients (96,6%). Conclusions: Psoriasis patients with the metabolic syndrome require the development of pathologically studied treatment methods to improve the efficiency of the therapeutic results and to prevent cardiovascular disorders.